STIMULATION OF MACROPHAGES WITH IFN-GAMMA OR TNF-ALPHA SHUTS OFF THE SUPPRESSIVE EFFECT PLAYED BY PGE(2)

被引：4

作者：

ZICARI, A

LIPARI, M

DIRENZO, L

SALERNO, A

LOSARDO, A

PONTIERI, GM

机构：

[1] Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Rome

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1995年 / 17卷 / 09期

关键词：

MACROPHAGES; ACTIVATION; IFN-GAMMA; TNF-ALPHA; PGE(2);

D O I：

10.1016/0192-0561(95)00045-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PGE(2) has been shown to be able to interfere with various lymphocyte and macrophage functions, but its effects on macrophage activation are still unclear. In this study, carried out on peritoneal macrophages obtained from healthy, tumour-bearing and Corynebacterium parvum-treated mice, we demonstrated that PGE(2) is involved in the down-regulation of macrophage activation, but it cannot exert its inhibiting effect when macrophages are further stimulated with activating cytokines, such as IFN gamma and TNF alpha. Our findings provide new insight into how macrophage tumoricidal activity may be induced and maintained even in presence of significant levels of PGE(2).

引用

页码：779 / 786

页数：8

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