MORPHINE DETERMINATION BY GAS-CHROMATOGRAPHY MASS-SPECTROSCOPY IN HUMAN VITREOUS-HUMOR AND COMPARISON WITH RADIOIMMUNOASSAY

被引:31
作者
BERMEJO, AM [1 ]
RAMOS, I [1 ]
FERNANDEZ, P [1 ]
LOPEZRIVADULLA, M [1 ]
CRUZ, A [1 ]
CHIAROTTI, M [1 ]
FUCCI, N [1 ]
MARSILLI, R [1 ]
机构
[1] UNIV CATTOLICA SACRO CUORE, INST FORENS MED, I-00168 ROME, ITALY
关键词
D O I
10.1093/jat/16.6.372
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A gas chromatographic-mass spectroscopic method (GC/MS) for morphine determination in human vitreous humor was developed. Reversed-phase solid-liquid extraction gave better sample purification compared with liquid-liquid or normalphase solid-liquid extractions. In 10 real cases of death by heroin overdose, the correlation between the results obtained by GC/MS and by radioimmunoassay (RIA) was studied. © 1992 Journal of Analytical Toxicology.
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页码:372 / 374
页数:3
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