SYNTHESIS OF NOVEL PHOSPHONATE ANALOG OF KDO AS A TOOL FOR THE DESIGN OF POTENT INHIBITORS FOR LIPOPOLYSACCHARIDE BIOSYNTHESIS

被引：9

作者：

SHEFFERDEENOOR, S ^{[1
]}

BELAKHOV, V ^{[1
]}

BAASOV, T ^{[1
]}

机构：

[1] TECHNION ISRAEL INST TECHNOL,DEPT CHEM,IL-32000 HAIFA,ISRAEL

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(00)73325-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new phosphonate analogue 3 of 2-deoxy-beta-Kdo (2) was prepared in a stereospecific manner via intramolecular C-C bond formation. X-Ray structure analysis and NMR studies of the cyclyzation product established the twist-boat conformation of the pyranose ring with alpha-anomeric configuration of the phosphonate linkage.

引用

页码：5077 / 5080

页数：4

共 26 条

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