SUPPRESSION OF ANTIPROLIFERATIVE EFFECTS OF TUMOR-NECROSIS-FACTOR BY TRANSFECTION OF CELLS WITH HUMAN PLATELET-DERIVED GROWTH-FACTOR B/C-SIS GENE

被引:8
作者
AGGARWAL, BB
POCSIK, E
TOTPAL, K
ALIOSMAN, F
机构
[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT BIOL THERAPY,HOUSTON,TX 77030
[2] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT EXPTL PEDIAT,HOUSTON,TX 77030
关键词
PLATELET-DERIVED GROWTH FACTOR (PDGF-B C-SIS); TNF; KINASE; RECEPTOR; CYTOKINE; RESISTANCE; GLUTATHIONE; PROLIFERATION;
D O I
10.1016/0014-5793(94)01299-G
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The growth of cells is determined by the balance between growth-stimulatory and growth-inhibitory signals, In the present study, we demonstrate that the transfection of NIH 3T3 cells with a platelet-derived growth factor (PDGF-Blc-sis) gene induces resistance to the anticellular effects of tumor necrosis factor (TNF), Human tumor cell lines that express elevated levels of c-sis (e.g. epidermoid carcinoma, A-431) are also TNF resistant, whereas those that express no significant levels of this gene (e.g. breast adenocarcinoma, MCF-7) are TNF sensitive, Transfection of cells with the c-sis gene leads to down-modulation of TNF receptors and also a decrease in intracellular glutathione levels, Thus, our results demonstrate that over-expression of PDGF-Blc-sis by certain tumor cells can lead to their protection from the anticellular effects of TNF.
引用
收藏
页码:1 / 6
页数:6
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