COMPUTER-SIMULATION OF AGITATION FLUIDIZED-BED GRANULATION BY A 2-DIMENSIONAL RANDOM ADDITION MODEL

被引：14

作者：

WATANO, S

MORIKAWA, T

MIYANAMI, K

机构：

[1] Department of Chemical Engineering, University of Osaka Prefecture, 1–1 Gakuen-cho, Sakai

来源：

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN | 1995年 / 28卷 / 02期

关键词：

GRANULATION; COMPUTER SIMULATION; RANDOM ADDITION MODEL; AGITATION FLUIDIZED BED; GRANULE GROWTH; SHAPE FACTOR; INTERNAL STRUCTURE;

D O I：

10.1252/jcej.28.171

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Computer simulation by a two-dimensional random addition model was proposed to elucidate the mechanisms of granule growth and compaction process of agitation fluidized bed granulation. In this paper, adhesion force by liquid bridge and separation force by agitator rotation were taken into consideration for adhesion probability of colliding granules. Effects of moisture content and agitator rotational speed on granule diameter, shape and internal structure were investigated theoretically. This simulation was applied to actual granulation, in which lactose and corn starch mixed in a weight ratio of 7:3 were granulated by an aqueous solution of hydroxypropylcellulose. Close agreement between simulated and experimental results was obtained.

引用

页码：171 / 178

页数：8

共 16 条

[1] BATCH PRODUCTION OF PHARMACEUTICAL GRANULATIONS IN A FLUIDIZED BED .1. EFFECTS OF PROCESS VARIABLES ON PHYSICAL PROPERTIES OF FINAL GRANULATION [J].