DIFFERENCES IN THE PLASMA-MEMBRANE PROTEINS OF CHRONIC-ALCOHOLIC RAT-BRAIN

被引：5

作者：

BABU, PP ^{[1
]}

NAGARAJU, N ^{[1
]}

VEMURI, MC ^{[1
]}

机构：

[1] UNIV HYDERABAD,SCH LIFE SCI,HYDERABAD 500134,ANDHRA PRADESH,INDIA

来源：

MEMBRANE BIOCHEMISTRY | 1990年 / 9卷 / 03期

关键词：

PLASMA MEMBRANE; MEMBRANE PROTEINS; ETHANOL; BRAIN; MEMBRANE DISRUPTION;

D O I：

10.3109/09687689009025843

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasma membranes were isolated from the cerebral cortex of control and chronic ethanol-treated rat brains. Analysis of protein composition by SDS-PAGE and by two-dimensional gel electrophoresis (IEF-SDS-PAGE) revealed significant differences in the membrane protein patterns between control and ethanol-treated rat cerebral cortices, indicating the loss of several proteins in membranes from ethanol-treated rat brains. Plasma membrane-associated protein species are categorized into ethanol-sensitive and -insensitive proteins, based on their response to ethanol. This study reports that ethanol depletes certain intrinsic proteins of membranes that might be responsible for plasma membrane disruption by ethanol.

引用

页码：227 / 237

页数：11

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