MOLECULAR STUDY OF 45,X CONCEPTUSES - CORRELATION WITH CLINICAL FINDINGS

被引：44

作者：

LORDASANCHEZ, I ^{[1
]}

BINKERT, F ^{[1
]}

MAECHLER, M ^{[1
]}

SCHINZEL, A ^{[1
]}

机构：

[1] UNIV ZURICH,INST MED GENET,RAMISTR 74,CH-8001 ZURICH,SWITZERLAND

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1992年 / 42卷 / 04期

关键词：

45; X; GONADAL DYSGENESIS; ORIGIN OF NONDISJUNCTION; PARENTAL ORIGIN OF SEX CHROMOSOME LOSS; TURNER SYNDROME;

D O I：

10.1002/ajmg.1320420414

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The parental origin of the single X in 45 cases (40 liveborns and 5 fetuses) with a 45,X karyotype was studied using polymorphic DNA probes. The single X was paternal in origin (X(p)) in 10 cases (22.2%) and maternal (X(m)) in 35 cases (77.8%). Y chromosome material was detected in 1 out of the 35 cases with a 45,X(m) constitution. Analysis of parental ages and clinical data of the patients with respect to the origin of the single X revealed no significant differences between the origins.

引用

页码：487 / 490

页数：4

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