TAUTOMERIC PHENOMENON OF A NOVEL POTENT IMMUNOSUPPRESSANT (FK506) IN SOLUTION .1. ISOLATION AND STRUCTURE DETERMINATION OF TAUTOMERIC COMPOUNDS

被引：37

作者：

NAMIKI, Y

KIHARA, N

KODA, S

HANE, K

YASUDA, T

机构：

[1] Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka,532, Chome, Kashima, Yodogawa-ku

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 07期

关键词：

D O I：

10.7164/antibiotics.46.1149

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tautomeric phenomenon was observed in the HPLC chromatogram obtained from a novel potent immunosuppressant, FK506, in ethanol solution. Two tautomeric compounds derived from FK506 were isolated and purified by HPLC. Their structures were elucidated by spectral analyses. The mechanisms for this tautomerization were also established based on the results of structure analysis.

引用

页码：1149 / 1155

页数：7

共 9 条

[1] 2 DISTINCT SIGNAL TRANSMISSION PATHWAYS IN LYMPHOCYTES-T ARE INHIBITED BY COMPLEXES FORMED BETWEEN AN IMMUNOPHILIN AND EITHER FK506 OR RAPAMYCIN [J].