SYNTHESIS OF A BAY-REGION TRIFLUOROMETHYL ANALOG OF A POTENT POLYCYCLIC AROMATIC CARCINOGEN

被引：9

作者：

COOMBS, MM

ZEPIK, HH

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 18期

关键词：

D O I：

10.1039/c39920001376

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

15,16-Dihydro-11-trifluoromethylcyclopenta[a]phenanthren-17-one 7, an electronegative analogue of the strongly carcinogenic 11-methyl-17-ketone, is synthesised in three steps from 17,17-ethylenedioxy-11,12,13,14,15,16-hexahydrocyclopenta[a]phenanthren-11-one 3.

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页码：1376 / 1377

页数：2

相关论文

共 15 条

[1] STEROIDAL CYCLIC KETALS .12. THE PREPARATION OF DELTA-16-STEROIDS [J].

ALLEN, WS ;

BERNSTEIN, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1955, 77 (04) :1028-1032

[2] CARCINOGENICITY AND MUTAGENICITY OF SOME ALKOXY CYCLOPENTA[A]-PHENANTHREN-17-ONES - EFFECT OF OBSTRUCTING THE BAY REGION [J].

BHATT, TS ;

HADFIELD, ST ;

COOMBS, MM .

CARCINOGENESIS, 1982, 3 (06) :677-680

[3] CARCINOGENICITY OF 15,16-DIHYDRO-11-METHYL-CYCLOPENTA[A]PHENANTHREN-17-ONE [J].

COOMBS, MM ;

BHATT, TS ;

YOUNG, S .

BRITISH JOURNAL OF CANCER, 1979, 40 (06) :914-921

[4]

COOMBS MM, 1979, CANCER RES, V39, P4160

[5]

COOMBS MM, 1973, CANCER RES, V33, P832

[6]

COOMBS MM, 1968, J CHEM SOC C, P955

[7]

COOMBS MM, 1987, CYCLOPENTAAPHENANTHR, pCH5

[8]

KASHINO S, 1986, CANCER RES, V46, P1817

[9] PREPARATION OF TRIFLUOROMETHYL AND OTHER PERFLUOROALKYL COMPOUNDS WITH (PERFLUORALKYL)TRIMETHYLSILANES [J].

KRISHNAMURTI, R ;

BELLEW, DR ;

PRAKASH, GKS .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (03) :984-989

[10] TETRACYCLIC AND PENTACYCLIC, NATURALLY-OCCURRING, AROMATIC-HYDROCARBONS IN RECENT SEDIMENTS [J].

LAFLAMME, RE ;

HITES, RA .

GEOCHIMICA ET COSMOCHIMICA ACTA, 1979, 43 (10) :1687-1691