DRUG-COMBINATION OF AZT AND DDL - SYNERGISM OF ACTION AND PREVENTION OF APPEARANCE OF AZT-RESISTANCE

被引：7

作者：

ANTONELLI, G

DIANZANI, F

BELLAROSA, D

TURRIZIANI, O

RIVA, E

GENTILE, A

机构：

[1] UNIV ROMA LA SAPIENZA,INST VIROL,I-00185 ROME,ITALY

[2] BRISTOL MYERS SQUIBB,ROME,ITALY

[3] UNIV PISA,DEPT BIOMED,VIROL SECT,I-56100 PISA,ITALY

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1994年 / 5卷 / 01期

关键词：

D O I：

10.1177/095632029400500108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Both 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxynosine (ddl) strongly inhibit the replication of human immunodeficiency virus type 1 (HIV-1). Here, it is shown that combination of AZT and ddl at concentrations that are readily achievable in vivo synergistically inhibit HIV-1 replication in C8166 cells and peripheral blood mononuclear cells. The synergism is significant even when the effect of AZT and ddl alone was negligible. Our findings show that AZT-resistance is less likely to occur when a combination of AZT and ddl is used. Particularly, generation of AZT-resistant strains by in vitro selection is prevented, or delayed, by the combination of AZT plus ddl. Taken together these observations provide a rationale for combination of AZT and ddl in the therapy of AIDS patients.

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页码：51 / 55

页数：5

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