FAILURE TO REPRODUCE THE IN-VITRO CARDIAC ELECTROPHYSIOLOGICAL EFFECTS OF NALOXONE IN HUMANS

被引：6

作者：

OLDROYD, KG ^{[1
]}

RANKIN, AC ^{[1
]}

GRAY, CE ^{[1
]}

HARVEY, K ^{[1
]}

BORLAND, W ^{[1
]}

RAE, AP ^{[1
]}

COBBE, SM ^{[1
]}

机构：

[1] ROYAL INFIRM, INST BIOCHEM, GLASGOW, SCOTLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1994年 / 37卷 / 03期

关键词：

NALOXONE; BETA-ENDORPHIN; CARDIAC ELECTROPHYSIOLOGY;

D O I：

10.1111/j.1365-2125.1994.tb04277.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 Opioid receptor antagonists such as naloxone have shown antiarrhythmic activity in animal models of coronary artery occlusion. Studies have indicated that these effects are stereospecific but both isomers of naloxone prolong action potential duration and refractoriness in guinea-pig and rabbit isolated ventricular myocardium (Class III effect). 2 This study was performed to identify whether this Class III effect of naloxone could be reproduced in human myocardium in vivo. Twenty patients with coronary artery disease received intravenous racemic naloxone (1-40 mu g kg(-1) min(-1)). Surface electrocardiographic parameters were measured and refractory periods were determined during fixed rate pacing by programmed stimulation. 3 The corrected QT interval during sinus rhythm (SR-QTc) was prolonged by 5(3)% (P = 0.06) at a dose of 20 mu g kg(-1) min(-1) and by 9(10)% at 40 mu g kg(-1) min(-1) (P = 0.03). These small changes were lost at higher paced heart rates. No significant effects on atrial, atrioventricular nodal or ventricular refractoriness were seen.

引用

页码：289 / 294

页数：6

共 22 条

[1] QUANTITATIVE AND PHARMACOKINETIC ANALYSIS OF NALOXONE IN PLASMA USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION AND SOLID-PHASE EXTRACTION [J].