CONTROL OF NEOPLASTIC CELL-PROLIFERATION AND DIFFERENTIATION BY RESTORATION OF 4-HYDROXYNONENAL PHYSIOLOGICAL CONCENTRATIONS

被引：46

作者：

FAZIO, VM

RINALDI, M

CIAFRE, S

BARRERA, G

FARACE, MG

机构：

[1] UNIV CATTOLICA SACRO CUORE, INST GEN PATHOL, I-00168 ROME, ITALY

[2] TOR VERGATA UNIV, DEPT EXPTL MED & BIOCHEM SCI, ROME, ITALY

[3] UNIV TURIN, DEPT EXPTL MED & ONCOL, I-10124 TURIN, ITALY

[4] CNR, INST EXPTL MED, ROME, ITALY

来源：

MOLECULAR ASPECTS OF MEDICINE | 1993年 / 14卷 / 03期

关键词：

D O I：

10.1016/0098-2997(93)90008-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several studies point to the existence of an inverse correlation between cellular lipid peroxidation and both cell proliferation and neoplastic transformation. In anaplastic cell lines products of membrane lipid peroxidation are very low or undetectable. Furthermore numerous results demonstrate effect of lipid peroxidation products on central biochemical pathways and intracellular signalling at physiological concentrations. 4-hydroxynonenal (HNE) is one of the most active products of lipid peroxidation. The restoration of HNE physiological concentrations in neoplastic cells may inhibit cell proliferation and modulate cell re-differentiation. This review try to summarize and critically discuss the effects of physiological concentrations of HNE on normal and neoplastic cell line.

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页码：217 / 228

页数：12

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