DIFFERENCES EXIST IN THE RELATIONSHIPS BETWEEN DIETARY LINOLEIC AND ALPHA-LINOLENIC ACIDS AND THEIR RESPECTIVE LONG-CHAIN METABOLITES

被引:76
作者
MANTZIORIS, E [1 ]
JAMES, MJ [1 ]
GIBSON, RA [1 ]
CLELAND, LG [1 ]
机构
[1] FLINDERS MED CTR,DEPT PAEDIAT & CHILD HLTH,BEDFORD PK,SA,AUSTRALIA
关键词
DIETARY ALPHA-LINOLENIC ACID; DIETARY LINOLEIC ACID; FLAXSEED OIL; PLASMA FATTY ACIDS; CELLULAR FATTY ACIDS; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; ARACHIDONIC ACID;
D O I
10.1093/ajcn/61.2.320
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Increased concentrations of cellular eicosapentaenoic acid (EPA) have been shown to be beneficial in coronary heart disease, hypertension, and inflammatory disorders. Successful long-term strategies for increasing cellular EPA concentrations require information on the relationships between cellular concentrations of EPA and dietary amounts of alpha-linolenic acid (alpha-LA), a precursor of EPA, and dietary amounts of linoleic acid (LA), an antagonist of alpha-LA conversion to EPA. A dietary intervention study with healthy human volunteers that incorporated alpha-LA-rich vegetable oil (flaxseed oil), against a background diet low in LA, allowed us to examine these relationships. Linear relationships were found between dietary alpha-LA and EPA in plasma fractions and in cellular phospholipids. By contrast there was no relationship observed between dietary LA and tissue concentrations of its metabolite, arachidonic acid (AA). There was an inverse relationship between dietary alpha-LA and docosahexaenoic acid concentrations in the phospholipids of plasma, neutrophils, mononuclear cells, and platelets. The results indicate that increasing dietary alpha-LA will elevate tissue EPA concentrations in a predictable manner. This insight will facilitate the rational planning of practical dietary strategies for the long-term elevation of EPA concentrations in tissues.
引用
收藏
页码:320 / 324
页数:5
相关论文
共 24 条
[1]  
ADAM O, 1986, J LIPID RES, V27, P421
[2]  
BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911
[3]   EFFECT OF DIETARY ALPHA-LINOLENIC ACID AND ITS RATIO TO LINOLEIC-ACID ON PLATELET AND PLASMA FATTY-ACIDS AND THROMBOGENESIS [J].
CHAN, JK ;
MCDONALD, BE ;
GERRARD, JM ;
BRUCE, VM ;
WEAVER, BJ ;
HOLUB, BJ .
LIPIDS, 1993, 28 (09) :811-817
[4]   LINOLEATE INHIBITS EPA INCORPORATION FROM DIETARY FISH-OIL SUPPLEMENTS IN HUMAN-SUBJECTS [J].
CLELAND, LG ;
JAMES, MJ ;
NEUMANN, MA ;
DANGELO, M ;
GIBSON, RA .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1992, 55 (02) :395-399
[5]  
CLELAND LG, 1988, J RHEUMATOL, V15, P1471
[6]   HIGH ALPHA-LINOLENIC ACID FLAXSEED (LINUM-USITATISSIMUM) - SOME NUTRITIONAL PROPERTIES IN HUMANS [J].
CUNNANE, SC ;
GANGULI, S ;
MENARD, C ;
LIEDE, AC ;
HAMADEH, MJ ;
CHEN, ZY ;
WOLEVER, TMS ;
JENKINS, DJA .
BRITISH JOURNAL OF NUTRITION, 1993, 69 (02) :443-453
[7]  
DAYTON S, 1966, J LIPID RES, V7, P103
[8]  
Emken EA, 1992, ESSENTIAL FATTY ACID, P23
[9]   INCORPORATION OF DIETARY OLEATE, LINOLEATE, ALPHA-LINOLENATE AND EICOSAPENTAENOATE INTO THE PLASMA-LIPID FRACTIONS OF 4 STRAINS OF RAT [J].
GIBSON, RA ;
JAMES, MJ ;
NEUMANN, MA ;
HAWKES, JS ;
CLELAND, LG .
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1126 (01) :49-52
[10]   EFFECT OF N-3 AND N-6 DIETARY FATS ON THE LIPOXYGENASE PRODUCTS FROM STIMULATED RAT NEUTROPHILS [J].
GIBSON, RA ;
NEUMANN, MA ;
JAMES, MJ ;
HAWKES, JS ;
HALL, C ;
CLELAND, LG .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1992, 46 (02) :87-91