FLUNARIZINE PROTECTS NEURONS FROM DEATH AFTER AXOTOMY OR NGF DEPRIVATION

被引：48

作者：

RICH, KM ^{[1
]}

HOLLOWELL, JP ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT NEUROBIOL,ST LOUIS,MO 63110

来源：

SCIENCE | 1990年 / 248卷 / 4961期

关键词：

D O I：

10.1126/science.2356470

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Systemically administered flunarizine enhanced neuronal survival in lumbar sensory ganglia in newborn rats after axotomy. Flunarizine-treated rats lost 71 percent fewer neurons than the untreated control rats at the end of 1 week. In cell culture, flunarizine at 30 to 40 μM also prevented neuronal death in nerve growth factor-dependent embryonic sensory and sympathetic neurons after the abrupt withdrawal of neurotrophic support. The drug may cause this effect by acting at an intracellular site, one distinct from its blockade of voltage-dependent calcium channels.

引用

页码：1419 / 1421

页数：3

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