ALBENDAZOLE - A MORE EFFECTIVE ANTIGIARDIAL AGENT INVITRO THAN METRONIDAZOLE OR TINIDAZOLE

被引：64

作者：

MELONI, BP ^{[1
]}

THOMPSON, RCA ^{[1
]}

REYNOLDSON, JA ^{[1
]}

SEVILLE, P ^{[1
]}

机构：

[1] SK&F LABS,BROOKVALE,NSW 2100,AUSTRALIA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 84卷 / 03期

关键词：

D O I：

10.1016/0035-9203(90)90324-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The effects of albendazole were assessed against Giardia duodenalis in vitro and compared with those of tinidazole and metronidazole. Trophozoite morphology, adherence and viability were markedly affected by albendazole, to a far greater extent than by either metronidazole or tinidazole. The results of this study, and in particular the superior potency of albendazole in vitro, are discussed with respect to its potential value as a new approach to the chemotherapy of giardiasis. © 1990, Royal Society of Tropical Medicine and Hygiene. All rights reserved.

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页码：375 / 379

页数：5

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