METAL-COMPLEXES OF THE ANTIINFLAMMATORY DRUG PIROXICAM

被引：145

作者：

CINI, R ^{[1
]}

GIORGI, G ^{[1
]}

CINQUANTINI, A ^{[1
]}

ROSSI, C ^{[1
]}

SABAT, M ^{[1
]}

机构：

[1] UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901

来源：

INORGANIC CHEMISTRY | 1990年 / 29卷 / 26期

关键词：

D O I：

10.1021/ic00351a012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis and characterization of Fe(II), Co(II), Zn(II), and Cd(II) complexes with a potent antiinflammatory drug piroxicam [4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide] are described. The crystal and molecular structures of M(Pir)2(DMF)2 (M = Cu, Cd; Pir = piroxicam; DMF = N,N-dimethylformamide) are also reported. Crystallographic data are as follows: Cd(Pir)2(DMF)2, monoclinic, P2(1)/c, a = 9.890 (2) angstrom, b = 8.076 (2) angstrom, c = 24.998 (4) angstrom, beta = 100.16 (2)degrees, Z = 2. The structure was refined to R(F(o)) = 0.039 for 2321 reflections with I > 3-sigma(I). Cu(Pir)2(DMF)2, monoclinic, P2(1)/c, a = 10.142 (2) angstrom, b = 7.855 (3) angstrom, c = 24.053 (4) angstrom, beta = 97.79 (2)degrees, Z = 2. The refinement yielded the final R(F(o)) of 0.059 for 797 reflections with I > 3-sigma(I). Both Cd(II) and Cu(II) ions bind to the piroxicam molecule through its amide O and pyridyl N atoms.

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页码：5197 / 5200

页数：4

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