INACTIVATION OF HUMAN CYSTATIN-C AND KININOGEN BY HUMAN CATHEPSIN-D

被引：80

作者：

LENARCIC, B ^{[1
]}

KRASOVEC, M ^{[1
]}

RITONJA, A ^{[1
]}

OLAFSSON, I ^{[1
]}

TURK, V ^{[1
]}

机构：

[1] UNIV LUND HOSP, DEPT CLIN CHEM, S-22185 LUND, SWEDEN

来源：

FEBS LETTERS | 1991年 / 280卷 / 02期

关键词：

CYSTATIN-C; KININOGEN; CATHEPSIN-D; PROTEINASE INHIBITOR INACTIVATION;

D O I：

10.1016/0014-5793(91)80295-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A papain inhibitor of 22 kDa was isolated from human placenta and shown to be identical to residues Cys246-Leu373 of the third domain of human kininogen. This kininogen domain and recombinant human cystatin C were inactivated by peptide bond cleavages at hydrophobic amino acid residues due to the action of cathepsin D. These results further support the proposed role of cathepsin D in the regulation of cysteine proteinase activity.

引用

页码：211 / 215

页数：5

共 32 条

[1] EFFICIENT PRODUCTION OF NATIVE, BIOLOGICALLY-ACTIVE HUMAN CYSTATIN-C BY ESCHERICHIA-COLI
ABRAHAMSON, M
DALBOGE, H
OLAFSSON, I
CARLSEN, S
GRUBB, A
[J]. FEBS LETTERS, 1988, 236 (01) : 14 - 18
[2] The estimation of pepsin, trypsin, papain, and cathepsin with hemoglobin
Anson, ML
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 1938, 22 (01) : 79 - 89
[3] THE PH-DEPENDENCE OF BREAKDOWN OF VARIOUS PURIFIED BRAIN PROTEINS BY CATHEPSIN-D PREPARATIONS
BANAYSCHWARTZ, M
BRACCO, F
DAHL, D
DEGUZMAN, T
TURK, V
LAJTHA, A
[J]. NEUROCHEMISTRY INTERNATIONAL, 1985, 7 (04) : 607 - 614
[4] Barrett A, 1977, PROTEINASES MAMMALIA, P209
[5] NEW ASSAY FOR CATHEPSIN B1 AND OTHER THIOL PROTEINASES
BARRETT, AJ
[J]. ANALYTICAL BIOCHEMISTRY, 1972, 47 (01) : 280 - &
[6] BARRETT AJ, 1981, METHOD ENZYMOL, V80, P771
[7] BARRETT AJ, 1986, RES MONOG CELL TISSU, V12, P515
[8] THE 2.0 A X-RAY CRYSTAL-STRUCTURE OF CHICKEN EGG-WHITE CYSTATIN AND ITS POSSIBLE MODE OF INTERACTION WITH CYSTEINE PROTEINASES
BODE, W
ENGH, R
MUSIL, D
THIELE, U
HUBER, R
KARSHIKOV, A
BRZIN, J
KOS, J
TURK, V
[J]. EMBO JOURNAL, 1988, 7 (08) : 2593 - 2599
[9] BODE W, 1990, BIOL CHEM H-S, V371, P111
[10] CAPONY F, 1989, CANCER RES, V49, P3904

← 1 2 3 4 →