NEUROTRANSMITTERS INHIBIT THE OMEGA-CONOTOXIN-SENSITIVE COMPONENT OF CA CURRENT IN NEUROBLASTOMA X GLIOMA HYBRID (NG 108-15) CELLS, NOT THE NIFEDIPINE-SENSITIVE COMPONENT

被引：35

作者：

CAULFIELD, MP

ROBBINS, J

BROWN, DA

机构：

[1] Department of Pharmacology, University College London, London, WC1E 6BT, Gower Street

来源：

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1992年 / 420卷 / 5-6期

关键词：

CALCIUM CURRENTS; NG-108-15; CELLS; DIHYDROPYRIDINE; ACETYLCHOLINE; NORADRENALINE; CONOTOXIN;

D O I：

10.1007/BF00374623

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Voltage-dependent calcium currents (I(Ca)) in NG 108-15 cells consisted of three pharmacologically distinct components: a transient low-voltage-activated (LVA) current, sensitive to Ni2+; a high-voltage-activated (HVA) current sensitive to the dihydropyridine antagonist, nifedipine and a HVA current sensitive to omega-conotoxin GVIA (CgTx). The voltage sensitivities and decay kinetics of the two HVA currents were indistinguishable. The neurotransmitters acetylcholine (ACh) and noradrenaline inhibited I(Ca). This inhibition was not occluded by Ni2+ or nifedipine, but was abolished by CgTx. It is therefore concluded that the neurotransmitter-sensitive component of I(Ca) is restricted to that component of HVA current inhibitable by omega-conotoxin.

引用

页码：486 / 492

页数：7

共 29 条

[1] NORADRENERGIC INHIBITION AND VOLTAGE-DEPENDENT FACILITATION OF OMEGA-CONOTOXIN-SENSITIVE CA CHANNELS IN INSULIN-SECRETING RINM5F CELLS [J].