REGULATION OF A RESTRICTION AND MODIFICATION SYSTEM VIA DNA INVERSION IN MYCOPLASMA-PULMONIS

被引：77

作者：

DYBVIG, K

YU, HL

机构：

[1] Department of Comparative Medicine, University of Alabama at Birmingham, Birmingham, Alabama, 35294

来源：

MOLECULAR MICROBIOLOGY | 1994年 / 12卷 / 04期

关键词：

D O I：

10.1111/j.1365-2958.1994.tb01041.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An invertible DNA element of 6.8kb, designated the hsd1 locus, was identified in the chromosome of Mycoplasma pulmonis. Infection of host cells with mycoplasma virus P1 revealed that the organism's restriction and modification (R-M) properties are controlled by inversion of hsd1. The nucleotide sequence of hsd1 revealed several genes, the predicted amino acids of which bear striking similarity to the subunits of the type I R-M enzymes previously found only in enteric bacteria.

引用

页码：547 / 560

页数：14

共 35 条

[1] HIGH-FREQUENCY REARRANGEMENTS IN THE CHROMOSOME OF MYCOPLASMA-PULMONIS CORRELATE WITH PHENOTYPIC SWITCHING [J].