NUCLEAR-MAGNETIC-RESONANCE STUDIES OF HYALURONAN (HA) - EVIDENCE OF COMPETITIVE-INHIBITION OF INTERCHAIN ASSOCIATIONS BY PHOSPHOLIPIDS WHICH MAY RESULT IN DECREASED ANTIINFLAMMATORY AND CARTILAGE PROTECTING PROPERTIES OF HA

被引：3

作者：

GHOSH, P ^{[1
]}

HUTADILOK, N ^{[1
]}

LENTINI, A ^{[1
]}

机构：

[1] CARLTON & UNITED BREWERIES LTD, GRP TECH SERV, MELBOURNE, VIC 3001, AUSTRALIA

来源：

HETEROCYCLES | 1994年 / 38卷 / 08期

关键词：

D O I：

10.3987/COM-93-S161

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chain flexibility of solutions of hyaluronan (HA) of different molecular weights was determined by H-1-nmr spectroscopy in the absence and presence of the phospholipid Dipalmitoyl DL-alpha-phosphatidylcholine (DPC). Sonication of high or low molecular weight HA with DPC for periods up to 60 min markedly increased HA chain flexibility as determined by observing the spin-spin relaxation times for the glucosamine acetyl group protons. From these data it is proposed that DPC competes for those hydrophobic centres along the HA chain which are normally responsible for the inter and intra chain interactions and which confer stiffness to the HA molecule.

引用

页码：1757 / 1774

页数：18

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