A GENERAL-ROUTE TO N'-(2,2-DIFLUORO-3-HYDROXYALKANOYL)NORNICOTINES

被引：8

作者：

FUKUDA, H ^{[1
]}

KITAZUME, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,DEPT BIOENGN,MIDORI KU,YOKOHAMA,KANAGAWA 227,JAPAN

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1995年 / 74卷 / 02期

关键词：

REFORMATSKY-TYPE REACTION; N'-SUBSTITUTED NORNICOTINES; ETHYL BROMODIFLUOROACETATE; NMR SPECTROSCOPY; HIGH-RESOLUTION MASS SPECTROMETRY; IR SPECTROSCOPY;

D O I：

10.1016/0022-1139(95)03268-I

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation of a variety of N'-(2,2-difluoro-3-hydroxyalkanoyl) nornicotines via a Reformatsky-type reaction of ethyl bromodifluoroacetate with aldehydes is described. The difluoromethylene unit may be regarded as an isopolar and isosteric replacement for ether oxygen.

引用

页码：171 / 176

页数：6

共 14 条

[1]

ABDELAAL YAI, 1986, SCIENCE, V223, P1073

[2] INHIBITION-KINETICS OF ACETYLCHOLINESTERASE WITH FLUOROMETHYL KETONES [J].