THE ANTERIOR OLFACTORY NUCLEUS IN PARKINSONS-DISEASE

被引：217

作者：

PEARCE, RKB

HAWKES, CH

DANIEL, SE

机构：

[1] INST NEUROL,UK PARKINSONS DIS SOC BRAIN BANK,LONDON WC1N 1PJ,ENGLAND

[2] IPSWICH HOSP,IPSWICH,SUFFOLK,ENGLAND

来源：

MOVEMENT DISORDERS | 1995年 / 10卷 / 03期

关键词：

PARKINSONS DISEASE; OLFACTORY SYSTEM; CELL COUNTS; NEURONAL LOSS;

D O I：

10.1002/mds.870100309

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Impaired olfaction occurs in patients with idiopathic Parkinson's disease (PD), and Lewy bodies have been found in the olfactory bulb and tract. We now confirm the latter finding and show that this presence of Lewy bodies is associated with significant neuronal loss. A quantitative study of the anterior olfactory nucleus (AON) was performed in tissue obtained postmortem from seven patients with PD and seven age-matched controls. Neuronal loss was seen in the PD bulb and tracts (p < 0.01), and a strong correlation of neuronal loss with disease duration was detected (R = -0.87). The presence of Lewy bodies was confirmed with immunocytochemical staining for ubiquitin in all the PD cases.

引用

页码：283 / 287

页数：5

共 26 条

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