DEPLETION OF MYELIN-BASIC-PROTEIN AUTOREACTIVE T-CELLS BY T-CELL VACCINATION - PILOT TRIAL IN MULTIPLE-SCLEROSIS

被引：108

作者：

MEDAER, R

STINISSEN, P

TRUYEN, L

RAUS, J

ZHANG, JW

机构：

[1] FREE UNIV AMSTERDAM,ACAD HOSP,DEPT DIAGNOST RADIOL,AMSTERDAM,NETHERLANDS

[2] CLIN DE MICK,MULTIPLE SCLEROSIS REHABIL UNIT,BRASSCHAAT,BELGIUM

来源：

LANCET | 1995年 / 346卷 / 8978期

关键词：

D O I：

10.1016/S0140-6736(95)91622-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a pilot trial, eight patients with multiple sclerosis were matched to control patients and received T-cell vaccination with irradiated T cells reactive to myelin basic protein (MBP) to deplete circulating MBP-reactive T cells. In the 2 years before and after vaccination, exacerbations decreased in five vaccinated patients (numbers 1, 2, 6-8) with relapsing-remitting disease from sixteen to three, respectively, and from twelve to ten in their matched controls. Magnetic resonance imaging showed a mean 8.0% increase in brain lesion size in the vaccinated patients compared with a 39.5% increase in the controls. Lesions and/or relapses worsened in three cases after Vaccination in association with reappearance of circulating MBP-reactive T cells.

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页码：807 / 808

页数：2

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