LONG-TERM FOLLOW-UP OF LOCAL EXCISION AND RADIATION-THERAPY FOR INVASIVE RECTAL-CANCER

被引:70
作者
FORTUNATO, L
AHMAD, NR
YEUNG, RS
COIA, LR
EISENBERG, BL
SIGURDSON, ER
YEH, K
WEESE, JL
HOFFMAN, JP
机构
[1] FOX CHASE CANC CTR, DEPT SURG, PHILADELPHIA, PA 19111 USA
[2] FOX CHASE CANC CTR, DEPT RADIAT ONCOL, PHILADELPHIA, PA 19111 USA
关键词
RECTAL CANCER; RADIOTHERAPY; LOCAL EXCISION; TRANSANAL EXCISION;
D O I
10.1007/BF02048336
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
PURPOSE: Little is known regarding the long-term outcome of patients with rectal cancer treated by local excision and radiation therapy. We updated our institutional experience with this approach. METHODS: From January 1986 to December 1991, 23 patients (median age, 64 (range, 30-80) years) with mobile, moderately differentiated adenocarcinoma of the rectum were offered transanal excision. Two patients with large T3 tumors, who were judged intraoperatively to be unsuited for a local procedure, received radical resection and were excluded from analysis. Twenty-one patients underwent transanal excision en bloc (14) or piecemeal (7) through a resectoscope. Seventeen patients (74 percent) had either extensive medical problems or refused a colostomy. Patients received a median of 5,040 cGy post operatively, and 15 also received 500 cGy preoperatively on protocol. Two patients received concomitant chemotherapy. Median follow-up is 56 months for all patients and 67 months for survivors (range, 27-92 months). RESULTS: There were 2 T1, 15 T2, and 4 T3 tumors. The distance from the anal verge was a median of 4 (range, 1-7) cm. The median tumor size was 3 (range, 2-7) cm. Sixteen patients had more than one-third of the wall involved. Four patients (19 percent) developed a local recurrence at 26, 30, 33, and 48 (median, 31.5) months. Three were salvaged (abdominoperineal resection = 2; low anterior resection = 1) and remain disease-free 18, 36, and 37 months postoperatively. Four patients (19 percent) developed metastases (lung = 3; liver = 1) at 3, 22, 25, and 44 months after initial treatment (median, 23.5 months). The actuarial five-year overall, disease-free and recurrence-free survival are 77, 75, and 58 percent, respectively. Twelve patients (57 percent) have no evidence of disease while retaining their rectum. There was one postoperative death. CONCLUSIONS: Long-term follow-up confirms that local excision and radiation therapy is of value in patients with mobile tumors of the rectum. It suggests that this treatment can be offered to those patients who refuse a colostomy or are medically compromised and may be an acceptable option for selected patients with T2 or T3, mobile adenocarcinomas of the rectum.
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页码:1193 / 1199
页数:7
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