SYNTHESIS OF (+)-8A,9-SECOARTEMISININ AND RELATED ANALOGS

被引：43

作者：

AVERY, MA

CHONG, WKM

DETRE, G

机构：

[1] Bio-Organic Chemistry Laboratory, Life Sciences Division, SRI International, Menlo Park, CA 94025

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)98789-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of (+)-8a,9-secoartemisinin 2, ring-D cleaved, tricyclic analog of (+)-artemisinin 1, has been accomplished. Dioxetane7, produced upon ozonolysis of vinyl-silane 5 in methanol, was intercepted with acid to provide the stable bicyclic peroxy-aldehyde9, which was readily converted to the title compound(s). © 1990 Pergamon Press plc.

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页码：1799 / 1802

页数：4

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