CONFIGURATION AND TOTAL ASSIGNMENT OF THE H-1-NMR AND C-13-NMR SPECTRA OF THE ALKALOID HOLSTIINE

被引:14
作者
CHERIF, A
MARTIN, GE
SOLTERO, LR
MASSIOT, G
机构
[1] UNIV REIMS,FAC PHARM,F-51100 REIMS,FRANCE
[2] UNIV HOUSTON,COLL PHARM,DEPT MED CHEM,HOUSTON,TX 77204
[3] RICE UNIV,DEPT CHEM,HOUSTON,TX 77005
来源
JOURNAL OF NATURAL PRODUCTS | 1990年 / 53卷 / 04期
关键词
D O I
10.1021/np50070a002
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The alkaloid holstiine [2] was reisolated from Strychnos henningsii and subjected to a total structural assignment through the concerted application of a number of two-dimensional nmr techniques that included COSY, HC-COSY, HOHAHA, NOESY, and proton-detected long-range heteronuclear chemical shift correlation (HMBC). The revised structure of holstiine proposed by Bisset et al. was rigorously confirmed by these methods. Unequivocal assignments of the1H- andl3C-nmr spectra of holstiine are reported. The stereochemistry of the 23-hydroxyl group is finally established as α on the basis of NOESY data. © 1990, American Chemical Society. All rights reserved.
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页码:793 / 802
页数:10
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