SYNTHESIS AND INCORPORATION OF METHYLENEOXY(METHYLIMINO) LINKED THYMIDINE DIMER INTO ANTISENSE OLIGONUCLEOSIDES

被引：20

作者：

DEBART, F ^{[1
]}

VASSEUR, JJ ^{[1
]}

SANGHVI, YS ^{[1
]}

COOK, PD ^{[1
]}

机构：

[1] ISIS PHARMACEUT,2280 FARADAY AVE,CARLSBAD,CA 92008

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

ANTISENSE; OLIGONUCLEOTIDES; NUCLEOSIDES; THYMIDINE DIMER; PHOSPHATE BACKBONE;

D O I：

10.1016/S0960-894X(00)80412-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient synthesis of a thymidine (T) nucleoside dimer (T-3'-CH2-0-NCH3-5'-T) 12 has been accomPlished via a nucleoside coupling reaction. An alternative synthesis of 3'-deoxy-3'-C-hydroxymethylthymidine is described. The new dimer and methodology is useful for the development of backbone-modified antisense oligonucleosides.

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页码：1479 / 1482

页数：4

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