SERUM IGG ANTIBODY TO GANGLIOSIDE GQ1B IS A POSSIBLE MARKER OF MILLER FISHER SYNDROME

被引:449
作者
CHIBA, A [1 ]
KUSUNOKI, S [1 ]
SHIMIZU, T [1 ]
KANAZAWA, I [1 ]
机构
[1] UNIV TOKYO,SCH MED,INST BRAIN RES,DEPT NEUROL,7-3-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN
关键词
D O I
10.1002/ana.410310619
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We studied serum anti-glycolipid antibodies by enzyme-linked immunosorbent assay and thin-layer chromatography-enzyme immunoassay in six consecutive patients with typical Miller Fisher syndrome. In all six, increased activity of IgG antibody against ganglioside GQ1b was present in the early phase and reduced with time, whereas such activity was not detected in normal control subjects and disease control subjects including those with Guillain-Barre syndrome. Anti-GQ1b IgG antibody is a new possible diagnostic marker of Miller Fisher syndrome and could well be related to the disease process itself.
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页码:677 / 679
页数:3
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