SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF OXAZOLIDIN-2-ONES AND RELATED HETEROCYCLES

被引：33

作者：

SENECI, P

CASPANI, M

RIPAMONTI, F

CIABATTI, R

机构：

[1] Marion Merrell Dow Research Institute, Lepetit Research Center, 21040 Geranzano (VA)

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 16期

关键词：

D O I：

10.1039/p19940002345

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 5-membered heterocycles, structurally related to the known antibacterial oxazolidin-2-ones 1, have been prepared by modifying the model compound la at the 1-, 2-, 2'- and 3-positions. The antibacterial activity of compound la was strongly affected by these modifications to the heterocycle. although none of these resulted in an improvement in the microbiological activity. The physicochemical and antibacterial properties of the synthesized compounds are reported.

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页码：2345 / 2351

页数：7

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