CYCLIC-AMP 2ND MESSENGER SIGNAL GENERATION IN EBV-TRANSFORMED LYMPHOBLASTOID-CELLS FROM SCHIZOPHRENIC-PATIENTS

被引：8

作者：

EBSTEIN, RP ^{[1
]}

BENNETT, ER ^{[1
]}

HADJEZ, J ^{[1
]}

SILVER, H ^{[1
]}

YEDGAR, S ^{[1
]}

LERER, B ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT BIOCHEM,IL-91010 JERUSALEM,ISRAEL

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 1990年 / 24卷 / 02期

关键词：

D O I：

10.1016/0022-3956(90)90052-R

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Several aspects of cyclic AMP second messenger signal generation were examined in EBV-transformed cell lines from 12 schizophrenic patients and 12 age-and sex-matched controls. No evidence was obtained suggesting a heritable abnormality in cyclic AMP synthesis in schizophrenia. Basal, forskolin, A1/NaF- and GppNHp-stimulated cyclic AMP synthesis in membranes from transformed cell lines was identical for schizophrenic and control subjects. In addition, no significant differences were observed for basal, forskolin-, isoproterenol- and prostaglandin E1-stimulated cyclic AMP accumulation in intact cell lines derived from ten of the schizophrenic patients compared with cell lines derived from ten of the control subjects. © 1990.

引用

页码：121 / 127

页数：7

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