ANTIMUTAGENIC ACTIVITIES OF NATURALLY-OCCURRING POLYAMINES IN CHINESE-HAMSTER OVARY CELLS-INVITRO

被引：11

作者：

COZZI, R ^{[1
]}

PERTICONE, P ^{[1
]}

BONA, R ^{[1
]}

POLANI, S ^{[1
]}

机构：

[1] UNIV ROME LA SAPIENZA,CNR,CTR GENET EVOLUT,I-00185 ROME,ITALY

来源：

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 1991年 / 18卷 / 03期

关键词：

PUVA; SISTER CHROMATID EXCHANGES; CHO CELLS; DNA STRUCTURE;

D O I：

10.1002/em.2850180308

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Spermine and spermidine, ubiquitous polyamines present in bacteria and animal cells, are also involved in cell growth. Since they interact with the double helix, they can stabilize the DNA molecule. Recent evidence of the antimutagenic and anticarcinogenic capacity of spermine has focused attention on the mechanism(s) by which such agents con protect cells from induced damages. In the present paper we show the ability of spermine and spermidine to decrease the level of sister chromatid exchanges induced in Chinese hamster ovary cells cultivated in vitro, by treating them with Psoralen + UVA irradiation (able to induce mainly monoadducts and DNA cross-links). Two different mechanisms of polyamine action can be invoked to explain the preservative activity of this class of agents.

引用

页码：207 / 211

页数：5

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