SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 3-VINYLTHIOMETHYLCEPHEM AND 3-VINYLTHIOMETHYLCEPHEM DERIVATIVES

被引:8
作者
NISHIMURA, S
YASUDA, N
SASAKI, H
KAWABATA, K
SAKANE, K
TAKAYA, T
机构
[1] New Drug Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Yodogawa-ku, Osaka 532
关键词
D O I
10.7164/antibiotics.43.1160
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The synthesis and biological properties of some 3-vinylthio- and 3-vinylthiomethylcephem derivatives are described. Both series possess potent antibacterial activity. Among them, 3-[(Z)-2-cyanovinylthiomethyl]cephem derivative was found to have an expanded antibacterial spectrum. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
引用
收藏
页码:1160 / 1168
页数:9
相关论文
共 8 条
[1]  
BATESON JH, 1980, RECENT ADV CHEM BETA, P291
[2]  
Kahan J. S., 1979, U.S. Pat., Patent No. [4,162,323, 4162323]
[3]  
KUKOLJA S, 1982, CHEM BIOL BETA LACTA, V1, P93
[4]   A NOVEL NATURALLY-OCCURRING CARBAPENEM ANTIBIOTIC, AB-110-D, PRODUCED BY KITASATOSPORIA-PAPULOSA NOVO SP [J].
NAKAMURA, Y ;
ISHII, K ;
ONO, E ;
ISHIHARA, M ;
KOHDA, T ;
YOKOGAWA, Y ;
SHIBAI, H .
JOURNAL OF ANTIBIOTICS, 1988, 41 (05) :707-711
[5]   SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 7-ALPHA-HYDROXYETHYL-1-OXACEPHEM DERIVATIVES [J].
NISHIMURA, S ;
SASAKI, H ;
YASUDA, N ;
MATSUMOTO, Y ;
KAMIMURA, T ;
SAKANE, K ;
TAKAYA, T .
JOURNAL OF ANTIBIOTICS, 1989, 42 (07) :1124-1132
[6]   SYNTHESIS AND BETA-LACTAMASE INHIBITORY ACTIVITY OF 7-ALPHA-HYDROXYETHYL CEPHEM DERIVATIVES [J].
NISHIMURA, S ;
YASUDA, N ;
SASAKI, H ;
MATSUMOTO, Y ;
KAMIMURA, T ;
SAKANE, K ;
TAKAYA, T .
JOURNAL OF ANTIBIOTICS, 1989, 42 (01) :159-162
[7]   THE GENERATION OF THE ETHENETHIOLATE ANION AND ITS REACTION WITH SEVERAL CHLOROMETHYL ALKYL ETHERS AND SULFIDES [J].
TANIMOTO, S ;
IKEHIRA, H ;
OIDA, T ;
KOKUBO, T .
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1983, 56 (04) :1261-1262
[8]   STUDIES ON BETA-LACTAM ANTIBIOTICS .9. SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A NEW ORALLY ACTIVE CEPHALOSPORIN, CEFIXIME (FK027) [J].
YAMANAKA, H ;
CHIBA, T ;
KAWABATA, K ;
TAKASUGI, H ;
MASUGI, T ;
TAKAYA, T .
JOURNAL OF ANTIBIOTICS, 1985, 38 (12) :1738-1751