GENOMIC STRUCTURE OF HUMAN MIDKINE (MK), A RETINOIC ACID RESPONSIVE GROWTH-DIFFERENTIATION FACTOR

被引：88

作者：

UEHARA, K

MATSUBARA, S

KADOMATSU, K

TSUTSUI, J

MURAMATSU, T

机构：

[1] Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Kagoshima 890

来源：

JOURNAL OF BIOCHEMISTRY | 1992年 / 111卷 / 05期

关键词：

D O I：

10.1093/oxfordjournals.jbchem.a123797

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Midkine (MK) is a product of a retinoic acid-responsive gene and a new heparin-binding growth/differentiation factor. The coding sequence of human MK was located on 1.5 kb DNA segment. The structure of the cloned human MK gene was determined and compared with that of the mouse gene. The coding sequence was divided into 4 exons, and each exon and exon-intron boundary was highly homologous to those of the mouse. Furthermore, 170 bases in the upstream region of the putative transcription initiation sites and 3 blocks of 200-350 bases in regions further upstream were highly conserved. These sequences are likely to be involved in developmentally regulated expression of MK.

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页码：563 / 567

页数：5

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