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DITERPENE QUINOIDES FROM TRIPTERYGIUM-WILFORDII VAR REGELII WHICH ARE INTERLEUKIN-1 INHIBITORS

被引：46
作者：
SHISHIDO, K
NAKANO, K
WARIISHI, N
TATEISHI, H
OMODANI, T
SHIBUYA, M
GOTO, K
ONO, Y
TAKAISHI, Y
机构：
[1] UNIV TOKUSHIMA,INST MED RESOURCES,TOKUSHIMA 770,JAPAN
[2] UNIV TOKUSHIMA,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN
[3] OTSUKA PHARMACEUT FACTORY INC,NEW DRUG RES LABS,TOKUSHIMA 772,JAPAN
[4] OTSUKA PHARMACEUT CO LTD,TOKUSHIMA 77101,JAPAN
来源：
PHYTOCHEMISTRY | 1994年 / 35卷 / 03期
关键词：
TRIPTERYGIUM WILFORDII; CELASTRACEAE; DITERPENE; TRIPTOQUINONE; INTERLEUKIN-1;
D O I：
10.1016/S0031-9422(00)90596-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Seven new quinoide-type diterpenes were isolated from the stems of Tripterygium wilfordii var. regelii and their structures were established on the basis of spectroscopic and chemical evidence. The isolated compounds showed extremely potent inhibitory activities against interleukin-1 alpha and beta releases for human peripheral mononuclear cells.
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页码：731 / 737
页数：7
相关论文
共 13 条
[1]   ALKALOIDS FROM TRIPTERYGIUM-WILFORDII HOOK - ISOLATION AND STRUCTURE OF WILFORZINE [J].
BEROZA, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1953, 75 (09) :2136-2138
[2]  
GHEZZI P, 1988, J IMMUNOL, V140, P4238
[3]  
HORI H, 1987, CHEM PHARM BULL, V35, P2125
[4]  
HORI H, 1987, CHEM PHARM BULL, V35, P4683
[5]  
Juling G., 1981, CHIN MED J, V94, P405
[6]   INDUCTION OF CYTOKINES IN HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS BY MYCOPLASMAS [J].
KITA, M ;
OHMOTO, Y ;
HIRAI, Y ;
YAMAGUCHI, N ;
IMANISHI, J .
MICROBIOLOGY AND IMMUNOLOGY, 1992, 36 (05) :507-516
[7]  
KUPCHAN SM, 1972, J AM CHEM SOC, V94, P7192
[8]   CYTO-TOXIC DITERPENES TRIPTOLIDE, TRIPDIOLIDE, AND CYTO-TOXIC TRITERPENES FROM TISSUE-CULTURES OF TRIPTERYGIUM-WILFORDII [J].
KUTNEY, JP ;
HEWITT, GM ;
KURIHARA, T ;
SALISBURY, PJ ;
SINDELAR, RD ;
STUART, KL ;
TOWNSLEY, PM ;
CHALMERS, WT ;
JACOLI, GG .
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1981, 59 (17) :2677-2683
[9]   AUGMENTED INTERLEUKIN-1 PRODUCTION AND HLA-DR EXPRESSION IN THE SYNOVIUM OF RHEUMATOID-ARTHRITIS PATIENTS - POSSIBLE INVOLVEMENT IN JOINT DESTRUCTION [J].
MIYASAKA, N ;
SATO, K ;
GOTO, M ;
SASANO, M ;
NATSUYAMA, M ;
INOUE, K ;
NISHIOKA, K .
ARTHRITIS AND RHEUMATISM, 1988, 31 (04) :480-486
[10]   STRUCTURES OF SESQUITERPENE POLYOL ESTERS FROM TRIPTERYGIUM-WILFORDII VAR REGELII [J].
TAKAISHI, Y ;
TAMAI, S ;
NAKANO, K ;
MURAKAMI, K ;
TOMIMATSU, T .
PHYTOCHEMISTRY, 1991, 30 (09) :3027-3031
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