TRANSDUCTION OF BINDING-ENERGY INTO HEMOGLOBIN COOPERATIVITY

被引：20

作者：

ACKERS, GK

HAZZARD, JH

机构：

[1] G.K. Ackers and J.H. Hazzard are, the Department of Biochemistry, Molecular Biophysics Washington University School of Medicine, St. Louis

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 10期

关键词：

D O I：

10.1016/0968-0004(93)90095-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hemoglobin is a tetrameric molecule consisting of two identical alphabeta dimers which assemble into either of two quaternary structures, T or R. Recent studies on mutant and partially ligated hemoglobins have revealed that cooperativity exists between the alpha and the beta hemes of each dimeric half-molecule and have led to a symmetry rule for quaternary T-->R switching: the quaternary R structure is energetically favored over the T structure when each dimeric half-molecule contains at least one ligated subunit.

引用

页码：385 / 390

页数：6

共 35 条

[1] THE ENERGETICS OF LIGAND-LINKED SUBUNIT ASSEMBLY IN HEMOGLOBIN REQUIRE A 3RD ALLOSTERIC STRUCTURE [J].

ACKERS, GK .

BIOPHYSICAL CHEMISTRY, 1990, 37 (1-3) :371-382

[2] ANALYSIS OF HEMOGLOBIN OXYGENATION FROM COMBINED EQUILIBRIUM AND KINETIC DATA - IS QUATERNARY ENHANCEMENT NECESSARY [J].

ACKERS, GK ;

JOHNSON, ML .

BIOPHYSICAL CHEMISTRY, 1990, 37 (1-3) :265-279

[3] LINKAGE BETWEEN OXYGENATION AND SUBUNIT DISSOCIATION IN HUMAN HEMOGLOBIN [J].

ACKERS, GK ;

HALVORSON, HR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (11) :4312-4316

[4] ENERGETICS OF SUBUNIT ASSEMBLY AND LIGAND-BINDING IN HUMAN-HEMOGLOBIN [J].

ACKERS, GK .

BIOPHYSICAL JOURNAL, 1980, 32 (01) :331-346

[5] MOLECULAR CODE FOR COOPERATIVITY IN HEMOGLOBIN [J].

ACKERS, GK ;

DOYLE, ML ;

MYERS, D ;

DAUGHERTY, MA .

SCIENCE, 1992, 255 (5040) :54-63

[6]

ATHA DH, 1979, J BIOL CHEM, V254, P2390

[7] HEMOGLOBIN - STRUCTURAL-CHANGES RELATED TO LIGAND-BINDING AND ITS ALLOSTERIC MECHANISM [J].

BALDWIN, J ;

CHOTHIA, C .

JOURNAL OF MOLECULAR BIOLOGY, 1979, 129 (02) :175-+

[8] EFFECTS OF PROTONS ON THE OXYGENATION-LINKED SUBUNIT ASSEMBLY IN HUMAN-HEMOGLOBIN [J].

CHU, AH ;

TURNER, BW ;

ACKERS, GK .

BIOCHEMISTRY, 1984, 23 (04) :604-617

[9] IDENTIFICATION OF THE INTERMEDIATE ALLOSTERIC SPECIES IN HUMAN HEMOGLOBIN REVEALS A MOLECULAR CODE FOR COOPERATIVE SWITCHING [J].

DAUGHERTY, MA ;

SHEA, MA ;

JOHNSON, JA ;

LICATA, VJ ;

TURNER, GJ ;

ACKERS, GK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1110-1114

[10]

DICKERSON RE, 1983, HEMOGLOBIN STRUCTURE

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