SYNTHESIS AND ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF SEVERAL PYRIMIDONE ANALOGS OF HUPERZINE-A

被引：15

作者：

KOZIKOWSKI, AP

CAMPIANI, G

SAXENA, A

DOCTOR, BP

机构：

[1] UNIV SIENA,DIPARTIMENTO FARMACO CHIM TECNOL,I-53100 SIENA,ITALY

[2] WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 02期

关键词：

D O I：

10.1039/c39950000283

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; beta-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.

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页码：283 / 285

页数：3

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