TRIIODOTHYRONINE DECREASES GAMMA-GLUTAMYL-TRANSPEPTIDASE EXPRESSION IN CULTURED RAT HEPATOCYTES

被引：3

作者：

DEMORI, I ^{[1
]}

BOTTAZZI, C ^{[1
]}

FUGASSA, E ^{[1
]}

机构：

[1] UNIV GENOA, IST FISIOL GEN, I-16132 GENOA, ITALY

来源：

HORMONE AND METABOLIC RESEARCH | 1995年 / 27卷 / 05期

关键词：

TRIIODOTHYRONINE; GGT EXPRESSION; RAT HEPATOCYTES;

D O I：

10.1055/s-2007-979944

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, an increase in gammaglutamyltranspeptidase (GGT) activity and mRNA in liver of hypothyroid rats has been reported. The aim of this study was to verify if triiodothyronine (T-3) can directly affect GGT expression in primary cultures of rat hepatocytes. Results obtained from adult rat hepatocytes cultured in serum-free medium demonstrate: 1) a rise in GGT mRNA level magnified by dexamethasone during the maintenance of hepatocytes in culture which parallels the stimulation of GGT activity; 2) a negative effect of T-3 on GGT activity of cultured hepatocytes which reflects a specific inhibition of GGT gene expression. The T-3 effect on GGT expression in cultured hepatocytes is in line with previous observations on hypothyroid rat liver suggesting an important role for thyroid hormone in maintaining the differentiated adult liver phenotype in the rat.

引用

页码：221 / 225

页数：5

共 19 条

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