REPRESENTATIVE SELECTION OF PROTEINS BASED ON NUCLEAR FAMILIES

被引：11

作者：

BOBERG, J

SALAKOSKI, T

VIHINEN, M

机构：

[1] UNIV TURKU,DEPT BIOCHEM,SF-20500 TURKU,FINLAND

[2] UNIV TURKU,DEPT COMP SCI,SF-20500 TURKU,FINLAND

[3] KAROLINSKA INST,NOVUM,CTR STRUCT BIOCHEM,S-14157 HUDDINGE,SWEDEN

来源：

PROTEIN ENGINEERING | 1995年 / 8卷 / 05期

关键词：

COMPLETE LINKAGE CLUSTERING; NOISE ELIMINATION; PDB FAMILIES; REPRESENTATIVE SELECTION;

D O I：

10.1093/protein/8.5.501

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The selection of unbiased representatives from a large database is complicated by the requirement for the chosen entries to be not only genuinely different from each other but also typical for the family of related entries. A method satisfying this 2-fold objective was developed by equipping complete linkage clustering with a novel noise elimination procedure to deal with overlapping cluster structure, A total of 200 nuclear families of truly related Brookhaven Protein Data Bank structures were generated, from which any entry can be chosen to represent its family.

引用

页码：501 / 503

页数：3

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