PERSISTENT LYMPHOCYTOSIS OF NATURAL-KILLER-CELLS IN AUTOIMMUNE THROMBOCYTOPENIC PURPURA (ATP) PATIENTS AFTER SPLENECTOMY

被引：18

作者：

GARCIASUAREZ, J

PRIETO, A

REYES, E

ARRIBALZAGA, K

PEREZMACHADO, MA

LOPEZRUBIO, M

MANZANO, L

ALVAREZMON, M

机构：

[1] UNIV ALCALA DE HENARES, HOSP PRINCIPE ASTURIAS, DEPT MED, SERV HEMATOL, MADRID, SPAIN

[2] UNIV ALCALA DE HENARES, HOS PRINCIPE ASTURIAS, DEPT MED, SERV IMMUNOL CLIN, MADRID, SPAIN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 89卷 / 03期

关键词：

AUTOIMMUNE THROMBOCYTOPENIC PURPURA; NATURAL KILLER CELLS; LARGE GRANULAR LYMPHOCYTES;

D O I：

10.1111/j.1365-2141.1995.tb08382.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report three patients with primary autoimmune thrombocytopenic purpura (ATP) who developed an absolute lymphocytosis (lymphocyte count >5x10(9)/l) after splenectomy and with a lymphocyte count between 5.4 and 8.9x10(9)/l. An immunophenotype study showed that the peripheral blood lymphocytosis was a persistent NK cell expansion (CD2(+), CD56(+), CD3(-)), and was characterized by a typical large granular lymphocytes (LGL) morphology. Two of these ATP patients were refractory to splenectomy.

引用

页码：653 / 655

页数：3

共 10 条

[1] THE CLINICAL OUTCOME OF AUTOIMMUNE THROMBOCYTOPENIC PURPURA PATIENTS IS RELATED TO THEIR T-CELL IMMUNODEFICIENCY [J].