INHIBITION OF PROTEIN-KINASE-C ACTIVATION BY LOW CONCENTRATIONS OF ALUMINUM

被引：33

作者：

COCHRAN, M ^{[1
]}

ELLIOTT, DC ^{[1
]}

BRENNAN, P ^{[1
]}

CHAWTUR, V ^{[1
]}

机构：

[1] FLINDERS UNIV,SCH BIOL SCI,BEDFORD PK,SA 5042,AUSTRALIA

来源：

CLINICA CHIMICA ACTA | 1990年 / 194卷 / 2-3期

关键词：

PROTEIN KINASE C; INHIBITION; ALUMINUM;

D O I：

10.1016/0009-8981(90)90131-B

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

An extract of rat brain protein kinase C was fully activated at a total calcium concentration 3 x 10 (-4) mol/l (Ca2+ 10(-4) mol/l) in the presence of non-limiting concentrations of phosphatidylserine. Available aluminium (ionised plus soluble hydrolysed) at a median value of 2 x 10(-8) mol/l inhibited enzyme activation by 90% at this non-limiting calcium concentration. Literature values for tissue aluminium concentrations suggest that interference with this key intracellular regulatory protein might occur in vivo.

引用

页码：167 / 172

页数：6