GRADED ACTION-POTENTIALS IN SMALL CULTURED RAT HIPPOCAMPAL-NEURONS

被引:6
作者
JOHANSSON, S
ARHEM, P
机构
[1] Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm
关键词
Action potential; Graded potential; Hippocampal neuron; Ion current; Mathematical model; Tight-seal recording; Voltage-clamp;
D O I
10.1016/0304-3940(90)90615-G
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The 'all-or-nothing' principle has been central to neurobiology since the beginning of this century. We here demonstrate that action potentials in small cultured neurons from the hippocampus of rat embryos clearly depend on stimulus strength and thus deviate from this principle. We also demonstrate that similar stimulus-dependent action potentials can be predicted from computations based on voltage-clamp measurements. The findings suggest that amplitude modulation of the action potential may be a principle for information processing in the mammalian nervous system. © 1990.
引用
收藏
页码:155 / 158
页数:4
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