IN-111 LEUKOCYTE SCINTIGRAPHY IN THE INVESTIGATION AND MANAGEMENT OF INFLAMMATORY BOWEL-DISEASE

The results of indium-111 tropolonate leukocyte scintigraphy in 105 patients with known inflammatory bowel disease are reviewed. Scintigraphy is as sensitive as radiology in detecting and assessing the extent of active colonic disease, and probably more sensitive in assessing small bowel disease. In a further 40 patients scintigraphy was successfully used as a screening test to identify, or exclude, bowel inflammation in patients with gastrointestinal symptoms. Scintigraphy has advantages over barium studies, being safe, non-invasive, more sensitive than small bowel radiology and giving additional information such as the bowel identification of intra-abdominal abscesses. The time required to label the leukocytes (about 2 hours) and the higher unit cost, unless many scintigrams are performed, are disadvantages.