SPERMINE - AN ANTIOXIDANT AND ANTIINFLAMMATORY AGENT

被引：94

作者：

LOVAAS, E

CARLIN, G

机构：

[1] Department of Physiology, Institute of Medical Biology, University of Tromsø, 9001 Tromsø

[2] Department of Inflammation Research, Pharmacia AB

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1991年 / 11卷 / 05期

关键词：

SPERMINE; ANTIINFLAMMATORY AGENT; POLYMORPHONUCLEAR LEUKOCYTES; HYALURONIC ACID; FREE RADICALS; HYDROXYL RADICALS;

D O I：

10.1016/0891-5849(91)90061-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This work demonstrates that spermine is a natural antioxidant and anti-inflammatory agent. It is found that: (1) Spermine inhibits the cytochrome C reduction initiated by FMLP- or PMA-stimulated human granulocytes. (2) Spermine inhibits the Fe(III)/xanthine oxidase stimulated lipid peroxidation of brain phospholipid liposomes. The antioxidative effect disappears at high Fe(III) concentrations. (3) Spermine forms a complex with Fe(II). (4) Spermine inhibits the Fe(II)-induced depolymerization of hyaluronic acid, and EDTA abolishes this effect. (5) Spermine or spermine-Fe(II) has no superoxide mimetic effect. These findings suggest that spermine has at least two antioxidative mechanisms of action: (I) Spermine inhibits the generation or the transport of superoxide radicals from stimulated granulocytes, and (II) Spermine inhibits the Haber-Weiss reaction by forming an unreactive chelate with Fe. Spermine thus prevents generation of destructive hydroxyl radicals.

引用

页码：455 / 461

页数：7

共 81 条

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