ASSIGNMENT OF THE H-1 AND C-13 NMR-SPECTRA OF THE C-21 STEROIDS 12-BETA-O-ACETYLTENACIGENIN-A AND TENACIGENIN-A BY 2-DIMENSIONAL NMR TECHNIQUES AND COMPUTER MODELING

被引：19

作者：

LUO, SQ

LIN, LZ

CORDELL, GA

XUE, LA

JOHNSON, ME

机构：

[1] UNIV ILLINOIS,COLL PHARM,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

[2] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,CHICAGO,IL 60612

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 1993年 / 31卷 / 03期

关键词：

2D NMR (DQF-COSY; ROESY; HETCOR; FLOCK); CONFORMATION; C-21; STEROIDS; 12-BETA-O-ACETYLTENACIGENIN-A; TENACIGENIN-A; MARSDENIA-TENACISSIMA;

D O I：

10.1002/mrc.1260310302

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stereochemical assignments of the C21 steroids 12-beta-O-acetyltenacigenin A and tenacigenin A were performed by use of two-dimensional phase-sensitive COSY, ROESY, H-1 and C-13 shift correlation spectroscopy (HETCOR and FLOCK), and ambiguous assignments were resolved through molecular modeling comparisons. This combination of techniques is applicable for the assignment of the highly overlapped H-1 signals of these steroids.

引用

页码：215 / 221

页数：7

共 23 条

[1] BROAD-BAND HOMONUCLEAR DECOUPLING IN HETERONUCLEAR SHIFT CORRELATION NMR-SPECTROSCOPY [J].