SERUM IGA IMMUNE-RESPONSE TO INDIVIDUAL ROTAVIRUS POLYPEPTIDES IN YOUNG-CHILDREN WITH ROTAVIRUS INFECTION

被引：24

作者：

JOHANSEN, K

GRANQVIST, L

KARLEN, K

STINTZING, G

UHNOO, I

SVENSSON, L

机构：

[1] KAROLINSKA INST,ST GORANS CHILDRENS HOSP,DEPT PEDIAT,S-11281 STOCKHOLM,SWEDEN

[2] KAROLINSKA CHILDRENS HOSP,STOCKHOLM,SWEDEN

[3] SWEDISH INST INFECT DIS CONTROL,DEPT IMMUNOL,S-10521 STOCKHOLM,SWEDEN

[4] UNIV UPPSALA HOSP,DEPT INFECT DIS,S-75185 UPPSALA,SWEDEN

来源：

ARCHIVES OF VIROLOGY | 1994年 / 138卷 / 3-4期

关键词：

D O I：

10.1007/BF01379129

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A human IgA-radioimmunoprecipitation assay (IgA-RIPA) utilizing the galactose-binding lectin jacalin from the jack-fruit Artrocarpus integrifolia was developed. Among the human immunoglobulins, jacalin binds specifically to immunoglobulin A. The IgA-RIPA was used to characterize the serum IgA response to individual rotavirus polypeptides in nine paired sera from children (8-34 months of age) with an acute rotavirus infection. In acute sera the IgA response was mainly directed against the inner capsid proteins VP2 and VP6, with VP2 surprisingly being the most immunogenic protein while in the convalescent sera, the IgA response was directed not only against structural but also against non-structural proteins.

引用

页码：247 / 259

页数：13

共 33 条

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