REQUIREMENT FOR A PHOSPHOLIPASE-C IN ODOR RESPONSE - OVERLAP BETWEEN OLFACTION AND VISION IN DROSOPHILA

被引：83

作者：

RIESGOESCOVAR, J ^{[1
]}

RAHA, D ^{[1
]}

CARLSON, JR ^{[1
]}

机构：

[1] YALE UNIV,DEPT BIOL,NEW HAVEN,CT 06520

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 07期

关键词：

ELECTROPHYSIOLOGY; NORPA GENE; SIGNAL TRANSDUCTION;

D O I：

10.1073/pnas.92.7.2864

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A central problem in sensory system biology is the identification of the signal transduction pathways used in different sensory modalities. Genetic analysis of transduction mutants provides a means of studying in vivo the contributions of different pathways. This report shows that odorant response in one olfactory organ of Drosophila melanogaster depends on the norpA phospholipase C (EC 3.1.4.3) gene, providing evidence for use of the inositol 1,4,5-trisphosphate (IP3) signal transduction pathway. Since the norpA gene is also essential to phototransduction, this work demonstrates overlap in the genetic and molecular underpinnings of vision and olfaction. Genetic and molecular data also indicate that some olfactory information flows through a pathway which does not depend on norpA.

引用

页码：2864 / 2868

页数：5

共 29 条

[1] OLFACTORY PHYSIOLOGY IN THE DROSOPHILA ANTENNA AND MAXILLARY PALP - ACJ6 DISTINGUISHES 2 CLASSES ODORANT PATHWAYS [J].