AN EPSTEIN-BARR VIRUS-PRODUCER LINE AKATA - ESTABLISHMENT OF THE CELL-LINE AND ANALYSIS OF VIRAL-DNA

被引：212

作者：

TAKADA, K

HORINOUCHI, K

ONO, Y

AYA, T

OSATO, T

TAKAHASHI, M

HAYASAKA, S

机构：

[1] HOKKAIDO UNIV,SCH MED,INST CANC,DEPT VIROL,SAPPORO,HOKKAIDO 060,JAPAN

[2] HOKKAIDO UNIV,SCH MED,DEPT SURG 1,SAPPORO,HOKKAIDO 060,JAPAN

来源：

VIRUS GENES | 1991年 / 5卷 / 02期

关键词：

EPSTEIN-BARR VIRUS; BURKITTS LYMPHOMA; B-CELL LINE; VIRUS PRODUCTION; VIRAL DNA; SOUTHERN ANALYSIS;

D O I：

10.1007/BF00571929

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An Epstein-Barr virus (EBV)-producer line, designated Akata, was established from a Japanese patient with Burkitt's lymphoma. The Akata line possessed the Burkitt's-type chromosome translocation, t(8q - ; 14 q +), and was derived from the tumor cell. Akata cells produced a large quantity of transforming virus upon treatment of cells with anti-immunoglobulin antibodies (Takada, 1984). Southern blot analysis of viral DNA indicated that the Akata EBV is nondefective and more representative of wild-type viruses. Akata cells should be useful as a source of EBV.

引用

页码：147 / 156

页数：10

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