CLINICALLY RELEVANT DIFFERENCES BETWEEN ANTIPSYCHOTIC COMPOUNDS

被引：10

作者：

SILVERSTONE, T

机构：

[1] Medical College of St Bartholomew's Hospital, London

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1990年 / 82卷

关键词：

antipsychotics; dopamine receptors; schizophrenia;

D O I：

10.1111/j.1600-0447.1990.tb05296.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Abstract All currently available antipsychotic drugs in general clinical use for the treatment of schizophrenia have in common the pharmacological property of dopamine receptor blockade and it is upon this that their antipsychotic effects are thought to depend. Where they differ is in the spectrum of side effects they may produce, in their clinical profile, in potency, and in time course. Such differences reflect variations in pharmacological properties, both pharmacodynamic and pharmacokinetic. The substituted benz‐amides (sulpiride, remoxipride) are highly selective D2 receptor blockers and this pharmacological specificity confers important clinical advantages. In practice the choice of which antipsychotic drug to use in any given clinical situation depends on the degree of psychopathology present, the purpose for which treatment is being given, and the patient's age and general physical health. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：88 / 91

页数：4

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