RELEASE OF IMMUNOREACTIVE [MET5]ENKEPHALIN AND CHOLECYSTOKININ FROM THE SPINAL-CORD BY BETA-ENDORPHIN ADMINISTERED INTRAVENTRICULARLY IN THE PENTOBARBITAL-ANESTHETIZED RAT

被引：15

作者：

TSENG, LF

HUANG, FY

机构：

[1] Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 215卷 / 2-3期

关键词：

BETA-ENDORPHIN; CCK-8S (SULFATED CHOLECYSTOKININ OCTAPEPTIDE); MET5]ENKEPHALIN; TAIL-FLICK INHIBITION;

D O I：

10.1016/0014-2999(92)90046-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

beta-Endorphin (4-mu-g) injected i.v.t. induced the release of immunoreactive [Met5]enkephalin and sulfated cholecystokinin octapeptide (CCK-8s) from the spinal cord in the pentobarbital-anesthetized rat. The inhibition of the tail-flick response induced by beta-endorphin given i.v.t. was antagonized by i.t. injection of CCK-8s and potentiated by i.t. administration of the antibody to CCK-8s. The findings give support to the hypothesis that endogenous CCK-8s in the spinal cord may play a negative feedback role in modulating beta-endorphin-induced antinociception.

引用

收藏

页码：309 / 312

页数：4

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