EFFECT OF CYCLOSPORINE-A ON RENAL CORTICAL RESISTANCES MEASURED BY COLOR DOPPLER FLOWMETRY ON RENAL GRAFTS

被引：21

作者：

DIPALO, FQ ^{[1
]}

RIVOLTA, R ^{[1
]}

ELLI, A ^{[1
]}

CASTAGNONE, D ^{[1
]}

PALAZZI, P ^{[1
]}

ABELLI, P ^{[1
]}

ZAFIROPULU, S ^{[1
]}

ZANUSSI, C ^{[1
]}

机构：

[1] OSPED MAGGIORE MILANO,SERV RADIOL,MILAN,ITALY

来源：

NEPHRON | 1993年 / 65卷 / 02期

关键词：

CYCLOSPORINE-A; NEPHROTOXICITY; ULTRASONOGRAPHY; COLOR DOPPLER STUDIES; RENAL BLOOD FLOW; RESISTIVE INDEX; PULSATILITY INDEX; RENAL TRANSPLANTATION;

D O I：

10.1159/000187481

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Doppler spectra were recorded at different cyclosporin A (CSA) levels (trough and peak) in 30 stable renal-transplanted outpatients: 15 with unimpaired renal function (plasma creatinine < 150 mumol/1) and 15 with renal impairment (plasma creatinine 150-350 mumol/l). Pulsatility (PI) and resistive indexes (RI) have been measured in the renal artery at the hilum and in the renal cortex. RI and PI were markedly increased (p < 0.0001) in the cortex at peak time while in the renal artery no significant changes were observed. These variations were statistically related with CSA blood levels (PI = p < 0.02; r = 0.54, RI = p < 0.05; r = 0.45). These effects were also found in the presence of renal damage. CSA dose-dependently reduces cortical blood flow, causing a persistent arteriolar vasoconstriction and a reduction in diastolic flow. This effect can be measured in man in a noninvasive and repeatable way using color Doppler sonograms.

引用

页码：240 / 244

页数：5

共 32 条

[1] RENAL-ALLOGRAFTS - PROSPECTIVE ANALYSIS OF DOPPLER SONOGRAPHY [J].